Methodological Foundations of Biomedical Informatics Fall 2014
 
 
The Sackler Institute of Graduate Biomedical Sciences at NYU School of Medicine
 
NYUMC Center for Health Informatics and Bioinformatics
 
NYUMC High Performance Computing Facility
Methodological Foundations of Biomedical Informatics Fall 2014 (BMSC-GA 4449)

Course Director: David Fenyö (David@FenyoLab.org)

Course Overview

This course provides an overview of foundational knowledge and essential methods relevant for all areas of biomedical informatics. Students will explore recurring themes and application domains most frequently used in the field. The course will be technical and rigorous, and it will include a number of computer science topics. The course content has been selected by the curriculum committee, and the topics will change over time. The majority of the coursework will be programming assignments and readings.

Learning objectives

The student will learn and understand the most commonly used methodologies in the field of biomedical informatics.

Course Assessment

  • Programming Assignments (40%).
  • Discussions (25%)
  • Final Project (35%)
Course Topics Lectures

In addition to the lectures listed below, the students should also attend the relevant lectures from Introduction to Biostatistics and Bioinformatics Fall 2014 (BMSC-GA 4451)

Lecture 1 Introduction (September 9, 2014 TRB 739 5pm)
Lecturer: Fenyo


Lecture 2 Algorithms (September 16, 2014 TRB 739 5pm)
Lecturer: Peskin & Fenyo
Homework (due date: December 16)

Reading List

  • The Algorithm Design Manual by Steven S Skiena, Chapters 1-4
  • Visualgo

    Additional Reading
  • Rosalind, Algorithm Heights
  • Coursera: Algorithms Part I
  • Coursera: Algorithms Part II


    Lecture 3 Linear Algebra (September 30, 2014 TRB 739 5pm)
    Lecturer: Fenyo
    Homework (due date: December 16)

    Reading List
  • Quick Review of Matrix and Real Linear Algebra by KC Border

    Additional Reading
  • Coursera: Coding the Matrix


    Lecture 4 Optimization (October 7, 2014 TRB 739 5pm)
    Lecturer: Fenyo
    Homework (due date: December 16)

    Reading List
  • An Introduction to Optimization Chapers 6-9, 19, 20

    Additional Reading
  • Coursera: Linear and Discrete Optimization


    Lecture 5 Statistics (October 14, 2014 TRB 739 5pm)
    Lecturer: Fenyo
    Homework (due date: December 16)

    Reading List
  • All of Statistics by Larry Wasserman, Chapters 1-3
  • Let's Give Statistics the Attention it Deserves

    Additional Reading
  • Think Stats by Allen B. Downey
  • Think Bayes by Allen B. Downey
  • An Introduction to Statistical Modeling of Extreme Values by Stuart Coles
  • All of Nonparametric statistics by Larry Wasserman


    Lecture 6 Machine Learning and Information Retrieval (October 21, 2014 TRB 739 5pm)
    Lecturer: Aphinyanaphongs & Fenyo
    Homework (due date: December 16)

    Reading List
  • An Introduction to Statistical Learning by Gareth James et al. Chapter 1-2
  • ROC Graphs: Notes and Practical Considerations for Researchers by Tom Fawcett
  • Information Retrieval by William Hersh Chapter 1-2

    Additional Reading
  • Coursera: Machine Learning
  • A Gentle Introduction to Support Vector Machines in Biomedicine: Theory and Methods (Volume 1) by Alexander Statnikov et al.
  • A Gentle Introduction to Support Vector Machines in Biomedicine: Case Studies and Benchmarks (Volume 2) by Alexander Statnikov et al.


    Lecture 7 Data visualization (October 30, 2014 TRB 739 5pm)
    Lecturer: Fenyo

    Reading List
  • Data visualization: A view of every Points of View column
  • Data Analysis with Open Source Tools by Philipp K. Janert

    Additional Reading
  • The Wall Street Journal Guide to Information Graphics: The Dos and Don'ts of Presenting Data, Facts, and Figures
  • Visualize This: The FlowingData Guide to Design, Visualization, and Statistics by Nathan Yau


    Lecture 8 Experimental design (November 11, 2014 TRB 739 5pm)
    Lecturer: Fenyo

    Reading List
  • Design and Analysis of Experiments by Douglas C. Montgomery
  • Adaptive clinical trials in oncology by Donald A. Berry, Nature Reviews Clinical Oncology 9 (2012) 199-207.
  • Bias as a threat to the validity of cancer molecular-marker research by David F. Ransohoff, Nat Rev Cancer 5 (2005) 142-149

    Additional Reading
  • Essentials of Clinical Research by Stephen P. Glasser
  • Handbook for Good Clinical Research Practice (GPC - WHO)


    Lecture 9 Signal Processing (November 18, 2014 TRB 739 5pm)
    Lecturer: Fenyo

    Additional Reading
  • Coursera Digital Signal Processing


    Lecture 10 Pathways and Networks (December 2, 2014 TRB 739 5pm)
    Lecturer: Fenyo

    Reading List
  • All of Statistics by Larry Wasserman, Chapters 16-18
  • The Algorithm Design Manual by Steven S Skiena, Chapter 5

    Additional Reading
  • An Introduction to Systems Biology: Design Principles of Biological Circuits by Uri Alon Chapters 1-4
  • Computational Modelling Of Gene Regulatory Networks - A Primer by Hamid Bolouri
  • Coursera: Probabilistic Graphical Models


    Lecture 11 Modeling and Simulation (December 9, 2014 TRB 739 5pm)
    Lecturer: Fenyo

    Reading List
  • All of Statistics by Larry Wasserman, Chapters 23-24
  • Modeling Complex Systems by Nino Boccara Chapters 1-2

    Additional Reading
  • Evolutionary Dynamics: Exploring the Equations of Life by Martin A. Nowak
  • Coursera: Dynamic Modeling Methods for Systems Biology
  • Monte Carlo Statistical Methods by Robert & Casella


    Lecture 12 Project Presentation (December 12, 2014 TRB 739 2:30pm)
    Lecturer: Fenyo